Boil rigatoni 2 minutes shorter than indicated by package instructions. Drain and set aside.
Meanwhile, mix together the marinara sauce, salt, Italian seasoning, garlic powder, onion powder, turkey pepperoni, 1 cup Italian-blend cheese, and Parmesan in a large bowl until evenly distributed.
Stir in the cooked and drained pasta.
Place pasta mixture into a lightly oiled 9x13-inch casserole dish.
Add remaining 1 cup Italian-blend cheese over the top.
Bake casserole for 10-15 minutes until the cheese is melted. If desired, broil for 2-3 minutes for a golden, bubbly top.